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Vitamin B12 deficiency is most common in adults over 50, vegans and vegetarians, pregnant women, and those with chronic health conditions like Crohns disease, inflammatory bowel disease (IBS), or rheumatoid arthritis

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Combining this with a PDE-5 medication (Viagra, Cialis) may be a successful combination, but should only be done when your medical provider is aware of your condition and medication use

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However, complete symptom resolution, particularly for neurological complications, may take several weeks to months depending on the severity and duration of deficiency before treatment

The annual dose should not exceed 600,000 IU as cholecalciferol